Phenotype Ferroptosis map
Ferroptosis@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / FERROPTOSIS  map

References
PMID:27048822
PMID:26653790
PMID:26794443
Ferroptosis is a regulated form of cell death driven by loss of activity of the lipid repair enzyme glutathione peroxidase 4 (GPX4) and subsequent accumulation of lipid-based reactive oxygen species (ROS), particularly lipid hydroperoxides.
PMID:17568748
PMID:28645028
PMID:27048813
PMID:28552631
Ferroptosis is characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrialmembrane rupture.
rc_re2346( Regulated Cell Death  map ):
PMID:27646922
Excess cellular levels of ROS cause damage to proteins, nucleic acids, lipids, membranes and organelles, which can lead to activation of cell death processes such as apoptosis.

Modifications:
In compartment: Cytosol
  1. Ferroptosis@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. ROS@Cytosol map → map Ferroptosis@Cytosol map
    As Catalyser: