Complex EZH2:HDAC1:HDAC2:SNAI1 map
Complex composition:

  1. HDAC2 map
  2. EZH2 map
  3. SNAI1 map
  4. HDAC1 map

EZH2:​HDAC1:​HDAC2:​SNAI1@Nucleus

Identifiers
NAME:EZH2:HDAC1:HDAC2:SNAI1

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map

References
PMID:22796940
Repression of E-cadherin by SNAI1/TWIST1 involves the recruitment of histone remodeling proteins to the promoter, where SNAI1 interacts with histone deacetylase HDAC1 and HDAC2.
PMID:21685935
EZH2 supports carcinoma cell aggressiveness by forming a co-repressor complex with HDAC1 and HDAC2 and Snail to inhibit E-cadherin.

Modifications:
Participates in complexes:
In compartment: Nucleus
  1. EZH2:​HDAC1:​HDAC2:​SNAI1@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. EZH2@Nucleus map + SNAI1@Nucleus map + HDAC1@Nucleus map + HDAC2@Nucleus map → map EZH2:​HDAC1:​HDAC2:​SNAI1@Nucleus map
As Catalyser:
  1. gE-Cadherin*@Nucleus map → map rE-Cadherin*@Nucleus map