Reaction heterodimer_association em_emtc_emtc_re1185 map

EZH2@Nucleus map + SNAI1@Nucleus map + HDAC1@Nucleus map + HDAC2@Nucleus map EZH2:​HDAC1:​HDAC2:​SNAI1@Nucleus map

No reaction regulators

References
PMID:22796940
Repression of E-cadherin by SNAI1/TWIST1 involves the recruitment of histone remodeling proteins to the promoter, where SNAI1 interacts with histone deacetylase HDAC1 and HDAC2.
PMID:21685935
EZH2 supports carcinoma cell aggressiveness by forming a co-repressor complex with HDAC1 and HDAC2 and Snail to inhibit E-cadherin.