Protein TKTL1 map

Identifiers
transketolase-like 1
HUGO:TKTL1 HGNC:11835 ENTREZ:8277 UNIPROT:P51854

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / GLUCOSE_METABOLISM  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map

TKTL1@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / GLUCOSE_METABOLISM  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map

References
rc_re1465( Regulated Cell Death  map ):
PMID:20103683
in head and neck squamous cell carcinoma cells, enhanced TKTL1 expression and promoter hypomethylation
TKTL1 overexpression associated with increased growth
increase in F6P and glyceraldehyde-3P
increase in glycolysis in a HIF1 dependent manner
they propose that TKTL1 promotes F6P and glyceraldehyde 3P, displayed here as the reverse reaction

Modifications:
In compartment: Cytosol
  1. TKTL1@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
      As Catalyser:
      1. xylulose-5P@Cytosol map + erythrose-4P@Cytosol map → map fructose-6P@Cytosol map + glyceraldehyde-3P@Cytosol map