Complex Vitronectin*:aVb3*_aVb5* map
Complex composition:

  1. Vitronectin* map
  2. aVb3*_aVb5* map

Vitronectin*:​aVb3*_aVb5*@Extracellular space

Identifiers
NAME:Vitronectin*:aVb3*_aVb5*

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map
 EMT Senescence  map  / CELL_MATRIX_ADHESIONS  map

References
PMID:19161977
In the endoplasmic reticulum, integrin subunits find their binding partners and form heterodimers.
Monomeric integrins never reach the cell surface.
Integrins a1b1, a2b1, a10b1 and a11b1 bind to collagens
PMID:12297042
Cell adhesion to components of the ECM is important in the angiogenesis
PMID:2153105
PMID:2786007
PMID:7639691
PMID:10809728
integrins are receptors for different ECM proteins: Collagen 1, 4; Laminin 1, 8; Fibronectin and Vitronectin
PMID:7522194
PMID:16195317
Interactions between integrins and the ECM proteins result in focal cell adhesion and cytoskeleton remodeling.
em_emtc_emtc_re958( EMT Senescence  map ):
Laminin-8 interacts with integrins.
em_emtc_emtc_re966( EMT Senescence  map ):
PMID:9822663
FYN is required for VAV1 phosphorylation and thus activation.
PMID:15699036
tyrosine phosphorylation of beta3 integrin and aVb3-mediated adhesion are required for VAV1 assocaition and Rho activation.
Vav1 associates with aVb3 upon cell adhesion to vitronectin

Modifications:
Participates in complexes:
In compartment: Extracellular space
  1. Vitronectin*:​aVb3*_aVb5*@Extracellular space map
Participates in reactions:
As Reactant or Product:
  1. aVb3*_aVb5*@Extracellular space map + Vitronectin*@Extracellular space map → map Vitronectin*:​aVb3*_aVb5*@Extracellular space map
  2. Vitronectin*:​aVb3*_aVb5*@Extracellular space map → map Cell-matrix adhesions@Extracellular space map
As Catalyser:
  1. VAV1@Cytosol map → map VAV1@Cytosol map