Protein Afadin* map

Identifiers
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
HUGO:MLLT4, HGNC:7137, ENTREZ:4301, UNIPROT:P55196, GENECARDS:GC06P168227 ??

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CELL_CELL_ADHESIONS  map
 EMT Senescence  map  / TIGHT_JUNCTIONS  map

References
PMID:9334353
MLLT4 is so-called Afadin or AF-6
Afadin serves as a linker of the Actin cytoskeleton to the plasma membrane at the TJ sites

Afadin*@Cytosol

References
em_emtc_emtc_re503( EMT Senescence  map ):
PMID:10613913
Cingulin is a functionally important component of TJ.
It interacts with ZO-1, ZO-2, ZO-3, and myosin thus links the submembrane plaque domain of TJ to the actomyosin cytoskeleton
em_emtc_emtc_re504( EMT Senescence  map ):
PMID:9334353
MLLT4 is so-called Afadin or AF-6
Afadin serves as a linker of the Actin cytoskeleton to the plasma membrane at the TJ sites

Modifications:
In compartment: Cytosol
  1. Afadin*@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. Afadin*:​ZO1*@Cytosol map
  2. Afadin*:​JAM1*@Cytosol map
  3. Afadin*:​Nectin*@Cytosol map
  4. Afadin*:​Cingulin*@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. Afadin*@Cytosol map + Cingulin*@Cytosol map → map Afadin*:​Cingulin*@Cytosol map
  2. Actin cytoskeletal*@Cytosol map + Afadin*@Cytosol map → map em_emtc_emtc_s2852
  3. JAM1*@Cytosol map + Afadin*@Cytosol map → map Afadin*:​JAM1*@Cytosol map
  4. Afadin*@Cytosol map + ZO1*@Cytosol map → map Afadin*:​ZO1*@Cytosol map
  5. Afadin*@Cytosol map + Nectin*@Cytosol map → map Afadin*:​Nectin*@Cytosol map
As Catalyser: