Phenotype NLRP3 activators map
NLRP3 activators@Extracellular space

Identifiers
NRLP3 activators

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / ER_STRESS  map
 Regulated Cell Death  map  / PYROPTOSIS  map

References
PMID:26885855
PMID:27048821
The NLRP3 inflammasome is activated in response to a broad variety of pathogen- and
danger-related activators :
Gram-negative bacteria, Staphylococcus aureus, RNA viruses, poreforming toxins, ionophores, crystals
K efflux, Ca2+ signaling,
mitochondria-derived reactive oxygen species (ROS),
cytosolic release of mitochondrial DNA and cardiolipin,
release of lysosomal cathepsins
PMID:27066895

Modifications:
In compartment: Extracellular space
  1. NLRP3 activators@Extracellular space map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. Potassium efflux@Extracellular space map → map NLRP3 activators@Extracellular space map
    2. Cathepsin*@Cytosol map → map NLRP3 activators@Extracellular space map
    3. gMT-DNA*@Mitochondrial inner membrane map → map NLRP3 activators@Extracellular space map
    4. ROS Production@Cytosol map → map NLRP3 activators@Extracellular space map
    As Catalyser:
    1. NLRP3@Cytosol map + NLRP3:​PYCARD@Cytosol map → map NLRP3:​PYCARD@Inflammasome platforms map