Protein B2M map

Identifiers
HUGO:B2M

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / SMAC  map

References
PMID:16181333 PMID:22076556 PMID:10358761
 DENDRITIC_CELL  map
PMID:16181333, PMID:22076556
Upon dissociation from CNX, the heavy chain of (MHC) class I binds ??2 microglobulin (b2m) and is incorporated into the peptide-loading complex.
PMID:10358761
All CD1 proteins studied to date are expressed on the surface of cells as type I transmembrane proteins that associate noncovalently with ??2-microglobulin
PMID:11717192
The gene expression of TAP1, TAP2, tapasin, ??2m and HLA-?? HC is up-regulated in mature DC.

Modifications:
In compartment: Endoplasmic Reticulum_Membrane
  1. B2M@Endoplasmic Reticulum_Membrane map
In compartment: PHAGOSOME/ENDOSOME/LYSOSOME_Membrane
  1. B2M@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
Participates in complexes:
In compartment: Cancer_cell
  1. B2M:​MHC_class_I*:​Tumor_antigen_fragment@Cancer_cell map
In compartment: Endoplasmic Reticulum_Membrane
  1. B2M:​MHC_class_I*@Endoplasmic Reticulum_Membrane map
  2. B2M:​MHC_class_I*:​Tumor_antigen_fragment@Endoplasmic Reticulum_Membrane map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. B2M:​CD1*:​Lipid_antigen@INNATE_IMMUNE_CELL_Membrane map
  2. B2M:​MHC_class_I*:​Tumor_antigen_fragment@INNATE_IMMUNE_CELL_Membrane map
In compartment: PHAGOSOME/ENDOSOME/LYSOSOME_Membrane
  1. B2M:​MHC_class_I*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
  2. B2M:​CD1*:​Lipid_antigen@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
  3. B2M:​MHC_class_I*:​Tumor_antigen_fragment@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
Participates in reactions:
As Reactant or Product:
  1. TCR_signaling_induction@Cancer_cell map → map B2M:​MHC_class_I*:​Tumor_antigen_fragment@Cancer_cell map
  2. B2M:​MHC_class_I*@Endoplasmic Reticulum_Membrane map + Tumor_antigen_fragment@Endoplasmic Reticulum_Membrane map → map B2M:​MHC_class_I*:​Tumor_antigen_fragment@Endoplasmic Reticulum_Membrane map
  3. B2M:​MHC_class_I*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map + Tumor_antigen_fragment@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map → map B2M:​MHC_class_I*:​Tumor_antigen_fragment@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
  4. B2M:​MHC_class_I*:​Tumor_antigen_fragment@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map → map B2M:​MHC_class_I*:​Tumor_antigen_fragment@INNATE_IMMUNE_CELL_Membrane map
  5. CD1*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map + B2M@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map + Lipid_antigen@INNATE_IMMUNE_CELL_Cytosol map → map B2M:​CD1*:​Lipid_antigen@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
  6. B2M:​CD1*:​Lipid_antigen@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map → map B2M:​CD1*:​Lipid_antigen@INNATE_IMMUNE_CELL_Membrane map
  7. B2M:​CD1*:​Lipid_antigen@INNATE_IMMUNE_CELL_Membrane map → map Antigen_presentation@default map
  8. B2M:​MHC_class_I*:​Tumor_antigen_fragment@Endoplasmic Reticulum_Membrane map → map B2M:​MHC_class_I*:​Tumor_antigen_fragment@INNATE_IMMUNE_CELL_Membrane map
  9. B2M:​MHC_class_I*:​Tumor_antigen_fragment@INNATE_IMMUNE_CELL_Membrane map → map Antigen_presentation@default map
  10. B2M:​MHC_class_I*@Endoplasmic Reticulum_Membrane map → map B2M:​MHC_class_I*@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
  11. B2M@Endoplasmic Reticulum_Membrane map + MHC_class_I*@Endoplasmic Reticulum_Membrane map → map B2M:​MHC_class_I*@Endoplasmic Reticulum_Membrane map
As Catalyser:
  1. LCK@cSMAC map + CD8*@cSMAC map → map CD8*:​LCK|​Y394_pho@cSMAC map
  2. CD247:​CD3*:​alpha_/beta_TCR*@cSMAC map → map CD247|​pho:​CD3*|​pho:​alpha_/beta_TCR*@cSMAC map + PTPRC@dSMAC map