Protein LCK map

Identifiers
HUGO:LCK

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / SMAC  map

References
PMID:23620508 PMID:21127503 PMID:9738502 PMID:19290918 PMID:10652356 PMID:17544292 PMID:9438848
CASCADE:KIR2DL3
CASCADE:NKP80
CASCADE:NKG2D
CASCADE:KNP44
CASCADE:NKP30
CASCADE:NKP46
CASCADE:Fc_gamma_RIII
 NATURAL_KILLER  map
PMID:12731048, PMID:20814939
Upon engagement of activating receptors, the tyrosine-containing adapters undergo tyrosine phosphorylation mediated by Src family kinases (SFKs)??.
Cross-linking of Nkp30 or Nkp46 or NKp44 resulted in strong tyrosine phosphorylation of LCK anf FYN kinases.
PMID:12740575
Src kinaze LCK participate in activation of NKG2D signaling and induction of PLCG phosphorylation, probably via DAP10 phosphorylation.
PMID:9751747, PMID:8986721
LCK phosphorylates KIR receptors in NK cells downstream of HLA binding.
PMID:22513334
Probably activated SHP-1 binds to Lck (through the Lck SH2 domain), which leads to dephosphorylation and inactivation of Lck by SHP-1 in NK cells (demonstrated in T cells).
PMID:9751747
KIR2DL3, KIR2DL1, KIR2DS4, KIR3DL1, KIR3DL2, KIR2DL4 interact with SHP-2 in NK cells
and probably are phosphorylated by LCK (directly demonstrated for KIR2DL3 only).
(CL6 = KIR2DL3,CL42 =KIR2DL1, CL39 = KIR2DS4, NKAT3= KIR3DL1, NKAT4 = KIR3DL2,KIR103AS=KIR2DL4)
PMID:8478617
Fc gamma RIII crosslinking results in activation of the src-related kinase p56lck in NK cells.
CD3 zeta is phosphorilated by LCK.

LCK|​pho|​active@INNATE_IMMUNE_CELL_Cytosol

References
in_re159( Innate Immunity  map ):
PMID:11062502, PMID:15536084
ERK1/2 activation induces perforin and granzyme B movement towards target tumor cells downstream of PI3K signaling in NK cells.
in_re258( Innate Immunity  map ):
PMID:8478617
Fc gamma RIII crosslinking results in activation of the src-related kinase p56lck in NK cells.
CD3 zeta is phosphorilated by LCK

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. LCK@INNATE_IMMUNE_CELL_Cytosol map
  2. LCK|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
In compartment: cSMAC
  1. LCK@cSMAC map
  2. LCK|​Y505_pho@cSMAC map
Participates in complexes:
In compartment: cSMAC
  1. CD4:​LCK|​Y394_pho@cSMAC map
  2. CD8*:​LCK|​Y394_pho@cSMAC map
Participates in reactions:
As Reactant or Product:
  1. LCK@cSMAC map + CD4@cSMAC map → map CD4:​LCK|​Y394_pho@cSMAC map
  2. LCK@cSMAC map + CD8*@cSMAC map → map CD8*:​LCK|​Y394_pho@cSMAC map
  3. LCK|​Y505_pho@cSMAC map → map LCK@cSMAC map
  4. LCK@cSMAC map → map LCK|​Y505_pho@cSMAC map
  5. LCK@INNATE_IMMUNE_CELL_Cytosol map → map LCK|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map
  6. LCK|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map → map LCK@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. CD226@T_cell map → map CD226|​pho|​active@T_cell map
  2. VAV1@T_cell map → map VAV1|​pho|​active@T_cell map
  3. ITK:​PIP3*@T_cell map → map (ITK|​pho:​PIP3*)|​active@T_cell map
  4. CD247:​CD3*:​alpha_/beta_TCR*@cSMAC map → map CD247|​pho:​CD3*|​pho:​alpha_/beta_TCR*@cSMAC map + PTPRC@dSMAC map
  5. CD247|​pho:​CD3*|​pho:​ZAP70:​alpha_/beta_TCR*@cSMAC map → map CD247|​pho:​CD3*|​pho:​ZAP70|​pho:​alpha_/beta_TCR*@cSMAC map
  6. DAG:​PRKCQ@cSMAC map → map (DAG:​PRKCQ|​pho)|​active@cSMAC map
  7. TRAT1@cSMAC map → map TRAT1|​pho@cSMAC map
  8. CRTAM@T_cell map + SCRIB@T_cell map → map CRTAM:​SCRIB@T_cell map
  9. rCRTAM@T_cell map → map CRTAM@T_cell map
  10. CD247:​NKp30*@INNATE_IMMUNE_CELL_Membrane map → map CD247|​pho:​NKp30*@INNATE_IMMUNE_CELL_Membrane map
  11. CD247:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane map → map CD247:​CD247|​pho:​FCER1G:​NKp46*@INNATE_IMMUNE_CELL_Membrane map
  12. GRB2@INNATE_IMMUNE_CELL_Cytosol map + DAP10:​NKG2D*@INNATE_IMMUNE_CELL_Membrane map → map DAP10|​pho:​GRB2:​NKG2D*@INNATE_IMMUNE_CELL_Membrane map
  13. CLEC2B:​NKp80*|​hm2@INNATE_IMMUNE_CELL_Membrane map → map (CLEC2B:​NKp80*|​pho|​hm2)|​active@INNATE_IMMUNE_CELL_Membrane map
  14. CD247:​Fc_gamma_RIII*@INNATE_IMMUNE_CELL_Membrane map + Immunoglobulins*@TUMOR_CELL_AS_INDUCTOR map + FCER1G@INNATE_IMMUNE_CELL_Membrane map → map CD247|​pho:​FCER1G|​pho:​Fc_gamma_RIII*:​Immunoglobulins*@INNATE_IMMUNE_CELL_Membrane map
  15. DAP12*:​NKp44*@INNATE_IMMUNE_CELL_Membrane map → map DAP12*|​pho:​NKp44*@INNATE_IMMUNE_CELL_Membrane map