Protein SEF* map

Identifiers
interleukin 17 receptor D
HUGO:IL17RD HGNC:17616 ENTREZ:54756 UNIPROT:Q8NFM7

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / MAPK  map

References
Sef1 which is a putative transmembrane protein of the Golgi apparatus seems to be a scaffold protein that recruits ERK1/2 and MEK1/2 to its vicinity and probably allows their activation by Golgi-localised Ras proteins.
Unlike many other scaffolds ERK1/2 do not dissociate from Sef1 upon stimulation and therefore nuclear translocation of the Sef1 anchored fraction of ERK1/2 molecules is blocked.
PMID:19565474 PMID:19565474

SEF*@Golgi Apparatus

References
su_mpk1_mpk1_re57( Survival  map ):
Sef1 which is a putative transmembrane protein of the Golgi apparatus seems to be a scaffold protein that recruits ERK1/2 and MEK1/2 to its vicinity and probably allows their activation by Golgi-localised Ras proteins.
PMID:19565474

Modifications:
In compartment: Golgi Apparatus
  1. SEF*@Golgi Apparatus map
Participates in complexes:
In compartment: Cytoplasm
  1. MEK*:​SEF*@Cytoplasm map
  2. ERK*|​pho|​pho:​MEK*|​pho|​pho:​SEF*@Cytoplasm map
  3. ERK*|​pho|​pho|​hm2:​MEK*|​pho|​pho:​SEF*@Cytoplasm map
In compartment: Golgi Apparatus
  1. ERK*:​MEK*:​SEF*@Golgi Apparatus map
Participates in reactions:
As Reactant or Product:
  1. ERK*|​pho|​pho:​MEK*|​pho|​pho:​SEF*@Cytoplasm map → map MEK*:​SEF*@Cytoplasm map + ERK*@Cytoplasm map
  2. MEK*@Cytoplasm map + ERK*@Cytoplasm map + SEF*@Golgi Apparatus map → map ERK*:​MEK*:​SEF*@Golgi Apparatus map
  3. ERK*:​MEK*:​SEF*@Golgi Apparatus map → map ERK*|​pho|​pho:​MEK*|​pho|​pho:​SEF*@Cytoplasm map
  4. ERK*|​pho|​pho:​MEK*|​pho|​pho:​SEF*@Cytoplasm map + ERK*|​pho|​pho@Cytoplasm map → map ERK*|​pho|​pho|​hm2:​MEK*|​pho|​pho:​SEF*@Cytoplasm map
As Catalyser:
  1. RSK*@Cytoplasm map → map RSK*|​pho@Cytoplasm map