Protein TP53 map

Identifiers
tumor protein p53
HUGO:TP53 hgnc_id:HGNC:11998 HGNC:11998 ENTREZ:7157 UNIPROT:P04637

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CAF_INHIBITION_ANTITUMOR  map

References
PMID:26302407
Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation
Levels of CSL, p53 and CDKN1A expression were all significantly decreased in lesion-adjacent stroma versus distant unaffected skin
PMID:24254977
Mouse models have validated the tumour-promoting effects of deleting Rb, Pten or p53 in fibroblasts that converts them from normal fibroblasts to carcinoma associated fibroblasts (CAFs).
PMID:19836055
P53 expression in tumor-stromal fibroblasts is closely associated with the nodal metastasis and outcome of patients with invasive ductal carcinoma who received neoadjuvant therapy

Modifications:
In compartment: Cytosol
  1. TP53@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. RBPJ:​TP53@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. TP53@Cytosol map → map NEGATIVE_REGULATORS OF_CAF@Cytosol map
  2. TP53@Cytosol map + RBPJ@Cytosol map → map RBPJ:​TP53@Cytosol map
  3. RBPJ:​TP53@Cytosol map → map NEGATIVE_REGULATORS OF_CAF@Cytosol map
As Catalyser: