Identifiers
interferon gamma receptor 1
HUGO:IFNGR1 hgnc_id:HGNC:5439 HGNC:5439 ENTREZ:3459 UNIPROT:P15260
HUGO:IFNGR1

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts   / CAF_INHIBITION_ANTITUMOR 
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity   / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS 

References
PMID:17683974
IFNG dimer binds to receptor contained two IFNGR1 and two IFNGR2 subunits.

References
ca_re268( Cancer Associated Fibroblasts  ):
PMID:22003200
IRF4 is a target of MIR125B1, inhibition of IRF4 by MIR125B1
resulted in increased surface expression of MHC II, CD40, CD86,
CD80 and IFNGR.
MIR125B potentiate response to IFNG, probably via
induction of IFNGR surface expression
and induces tumoricidal activity of macrophages.

References
in_re692( Innate Immunity  ):
PMID:22003200
IRF4 is a target of MIR125B1, inhibition of IRF4 by MIR125B1
resulted in increased surface expression of MHC II, CD40, CD86,
CD80 and IFNGR.
MIR125B potentiate response to IFNG, probably via
induction of IFNGR surface expression
and induces tumoricidal activity of macrophages.

1. IFNGR1@Cytosol

1. IFNGR1@INNATE_IMMUNE_CELL_Membrane

1. IFNGR1:​IFNGR2@Cytosol
2. IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@Cytosol

1. IFNGR1:​IFNGR2@INNATE_IMMUNE_CELL_Membrane
2. IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@INNATE_IMMUNE_CELL_Membrane

1. IFNGR1@Cytosol + IFNGR2@Cytosol → IFNGR1:​IFNGR2@Cytosol
2. IFNG|​hm2@default + IFNGR1:​IFNGR2@Cytosol + JAK2@Cytosol + JAK1@Cytosol → IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@Cytosol
3. IFNG|​hm2@default + IFNGR1:​IFNGR2@INNATE_IMMUNE_CELL_Membrane + JAK1@INNATE_IMMUNE_CELL_Cytosol + JAK2@INNATE_IMMUNE_CELL_Cytosol → IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@INNATE_IMMUNE_CELL_Membrane
4. IFNGR1@INNATE_IMMUNE_CELL_Membrane + IFNGR2@INNATE_IMMUNE_CELL_Membrane → IFNGR1:​IFNGR2@INNATE_IMMUNE_CELL_Membrane

1. STAT1@Cytosol → STAT1|​pho@Cytosol
2. STAT1@INNATE_IMMUNE_CELL_Cytosol → STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol