Complex IFNGR1:IFNGR2 map
Complex composition:

  1. IFNGR1 map
  2. IFNGR2 map

IFNGR1:​IFNGR2@Cytosol

Identifiers
NAME:IFNGR1:IFNGR2

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CAF_INHIBITION_ANTITUMOR  map

References
PMID:17683974
IFNG dimer binds to receptor contained two IFNGR1 and two IFNGR2 subunits.
PMID:19833085
IFNG receptor is assosiated with kinases JAK1 and JAK2.
Ligand engagement of the IFNG receptor leads to activation of receptor-associated Jak1 and Jak2 and phosphorylation of a receptor tyrosine residue
(Y440) that serves as a docking site for STAT1, which exists in a latent state in the cytoplasm.
ca_re268( Cancer Associated Fibroblasts  map ):
PMID:22003200
IRF4 is a target of MIR125B1, inhibition of IRF4 by MIR125B1
resulted in increased surface expression of MHC II, CD40, CD86,
CD80 and IFNGR.
MIR125B potentiate response to IFNG, probably via
induction of IFNGR surface expression
and induces tumoricidal activity of macrophages.

IFNGR1:​IFNGR2@INNATE_IMMUNE_CELL_Membrane

Identifiers
NAME:IFNGR1:IFNGR2

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS  map

References
PMID:17683974
IFNG dimer binds to receptor contained two IFNGR1 and two IFNGR2 subunits.
PMID:19833085
IFNG receptor is assosiated with kinases JAK1 and JAK2.
Ligand engagement of the IFNG receptor leads to activation of receptor-associated Jak1 and Jak2 and phosphorylation of a receptor tyrosine residue
(Y440) that serves as a docking site for STAT1, which exists in a latent state in the cytoplasm.
in_re692( Innate Immunity  map ):
PMID:22003200
IRF4 is a target of MIR125B1, inhibition of IRF4 by MIR125B1
resulted in increased surface expression of MHC II, CD40, CD86,
CD80 and IFNGR.
MIR125B potentiate response to IFNG, probably via
induction of IFNGR surface expression
and induces tumoricidal activity of macrophages.

Modifications:
Participates in complexes:
In compartment: Cytosol
  1. IFNGR1:​IFNGR2@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. IFNGR1:​IFNGR2@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. IFNGR1@Cytosol map + IFNGR2@Cytosol map → map IFNGR1:​IFNGR2@Cytosol map
  2. IFNG|​hm2@default map + IFNGR1:​IFNGR2@Cytosol map + JAK2@Cytosol map + JAK1@Cytosol map → map IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@Cytosol map
  3. IFNG|​hm2@default map + IFNGR1:​IFNGR2@INNATE_IMMUNE_CELL_Membrane map + JAK1@INNATE_IMMUNE_CELL_Cytosol map + JAK2@INNATE_IMMUNE_CELL_Cytosol map → map IFNGR1|​pho:​IFNGR2:​IFNG|​hm2:​JAK1:​JAK2@INNATE_IMMUNE_CELL_Membrane map
  4. IFNGR1@INNATE_IMMUNE_CELL_Membrane map + IFNGR2@INNATE_IMMUNE_CELL_Membrane map → map IFNGR1:​IFNGR2@INNATE_IMMUNE_CELL_Membrane map
As Catalyser: