Protein EGR1 map

Identifiers
early growth response 1
HUGO:EGR1 hgnc_id:HGNC:3238 HGNC:3238 ENTREZ:1958 UNIPROT:P18146
HUGO:EGR1

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CORE  map

References
CASCADE:TGFB
PMID:17559085
The human p300 gene has been recently cloned. The regulatory region is highly GC-rich, and contains six early growth response 1 (Egr-1) binding sites, along with serum response elements and Sp1 binding sites (Yu et al., 2004).
Ectopic expression of Egr-1 in skin fibroblasts by itself stimulated basal p300 gene expression, and further enhanced the stimulation induced by TGF-??. Furthermore, reporter constructs driven by p300 promoter fragments harboring mutations in the Egr-1 binding sites failed to respond to TGF-?? in transient transfection assays (Ghosh et al., unpublished data). These observations establish a critical role for Egr-1 in the regulation of p300 gene expression by TGF-?? in normal fibroblasts.

EGR1@Nucleus

References
mo_re123:( motility  map ) PMID:19945467

Modifications:
In compartment: Cytosol
  1. EGR1@Cytosol map
In compartment: Nucleus
  1. EGR1@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. EGR1@Cytosol map → map EGR1@Cytosol map
    2. rEGR1@Nucleus map → map EGR1@Nucleus map
    As Catalyser:
    1. gEP300@Cytosol map → map rEP300@Cytosol map
    2. gPIRH2*@Nucleus map → map rPIRH2*@Nucleus map