Protein GPX4 map

Identifiers
glutathione peroxidase 4
HUGO:GPX4 hgnc_id:HGNC:4556 HGNC:4556 ENTREZ:2879 UNIPROT:P36969

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / FERROPTOSIS  map
 RECON2  map

References
PMID:27048822
PMID:26653790
PMID:26794443
Ferroptosis is a regulated form of cell death driven by loss of activity of the lipid repair enzyme glutathione peroxidase 4 (GPX4) and subsequent accumulation of lipid-based reactive oxygen species (ROS), particularly lipid hydroperoxides.

Modifications:
In compartment: Cytosol
  1. GPX4@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. GPX4:​L-selenocysteine@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. GPX4@Cytosol map + L-selenocysteine@Cytosol map → map GPX4:​L-selenocysteine@Cytosol map
  2. rGPX4@Cytosol map → map GPX4@Cytosol map
As Catalyser:
  1. GSH@Cytosol map + H_sub_2_endsub_O_sub_2_endsub_@Cytosol map → map GSSG@Cytosol map