Protein EP300 map

Identifiers
E1A binding protein p300
HUGO:EP300 hgnc_id:HGNC:3373 HGNC:3373 ENTREZ:2033 UNIPROT:Q09472

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CORE  map

References
CASCADE:TGFB
PMID:15265520
The role for CREB binding protein (CBP) and p300 as essential coactivators for SMAD-driven gene expression has been well documented and competition for p300/CBP has been suggested to mediate some examples of signal-induced transcriptional repression.
PMID:10918613
For Smad-dependent stimulation of collagen (COL1A2 )synthesis, the interaction of activated Smad2/3 with p300 is essential (Ghosh et al., 2001, 2004a). Furthermore, the acetyltransferase activity of p300 is required for maximal stimulation as shown by the fact that fibroblasts transfected with HAT-deleted mutants of p300 showed markedly reduced TGF-?? stimulation of COL1A2 promoter activity (Ghosh et al., 2000).

Modifications:
In compartment: Cytosol
  1. EP300@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. EP300:​STAT1@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. rEP300@Cytosol map → map EP300@Cytosol map
  2. EP300@Cytosol map + STAT1|​pho@Cytosol map → map EP300:​STAT1@Cytosol map
  3. CREBBP@Cytosol map + EP300@Cytosol map → map ca_s4253
As Catalyser:
  1. gCollagens*@Cytosol map → map rCollagens*@Cytosol map