Complex EP300:STAT1 map
Complex composition:

  1. STAT1 map
  2. EP300 map

EP300:​STAT1@Cytosol

Identifiers
NAME:EP300:STAT1

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CORE  map

References
CASCADE:IFNG
PMID:17559085, PMID:11134049
IFN-?? induced a direct interaction between activated STAT1?? and p300 in normal skin fibroblasts (Ghosh et al., 2001). Furthermore, ectopic expression of p300 overcame the inhibition by IFN-?? and rescued stimulation by TGF-??, suggesting that in response to IFN-??, activated STAT1?? and/or downstream factor(s) sequestered p300, preventing its recruitment to the transcriptional machinery and thereby inhibiting collagen gene transcription (Ghosh et al., 2001). Similarly, IFN-?? suppression of COL1A2 promoter activation by YB-1 also appears to involve p300 sequestration (Higashi et al., 2003).

Modifications:
Participates in complexes:
In compartment: Cytosol
  1. EP300:​STAT1@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. EP300@Cytosol map + STAT1|​pho@Cytosol map → map EP300:​STAT1@Cytosol map
As Catalyser:
  1. gCollagens*@Cytosol map → map rCollagens*@Cytosol map