Protein S1PR* map

Identifiers
HUGO:S1PR1 HUGO:S1PR3
HUGO:S1PR1 HUGO:S1PR2 HUGO:S1PR3 HUGO:S1PR4 HUGO:S1PR5

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / DANGER_SIGNAL_PATHWAYS  map
 Innate Immunity  map  / RECRUITMENT_OF_IMMUNE_CELLS  map

References
PMID:23747852 PMID:11324699 PMID:22975327 PMID:18541717 PMID:20335228
 DENDRITIC_CELL  map
CASCADE:S1PR
PMID:11919175
Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses.
Immature and mature DC express the mRNA for different S1P receptors, such as endothelial differentiation gene (EDG)-1, EDG-3, EDG-5, and
EDG-6. In immature DC, S1P stimulated pertussis toxin-sensitive Ca2+ increase actin polymerization and chemotaxis. These responses were lost by DC matured with
lipopolysaccharide. In maturing DC, however, S1P inhibited the secretion of tumor necrosis

Modifications:
In compartment: Extracellular Matrix
  1. S1PR*@Extracellular Matrix map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. S1PR*@INNATE_IMMUNE_CELL_Membrane map
Participates in complexes:
In compartment: Extracellular Matrix
  1. S1PR*:​Sphingosine-1-phosphate@Extracellular Matrix map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. S1PR*:​Sphingosine 1-phosphate@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. S1PR1@Extracellular Matrix map → map S1PR*@Extracellular Matrix map
  2. Sphingosine-1-phosphate@Extracellular Matrix map + S1PR*@Extracellular Matrix map → map S1PR*:​Sphingosine-1-phosphate@Extracellular Matrix map
  3. S1PR3@Extracellular Matrix map → map S1PR*@Extracellular Matrix map
  4. S1PR*:​Sphingosine-1-phosphate@Extracellular Matrix map → map VE-Cadherin*@Cytosol map
  5. S1PR*:​Sphingosine 1-phosphate@INNATE_IMMUNE_CELL_Membrane map → map RECRUITMENT_OF_IMMUNE_CELLS@INNATE_IMMUNE_CELL_Cytosol map
  6. Sphingosine 1-phosphate@TUMOR_CELL_AS_INDUCTOR map + S1PR*@INNATE_IMMUNE_CELL_Membrane map → map S1PR*:​Sphingosine 1-phosphate@INNATE_IMMUNE_CELL_Membrane map
As Catalyser:
  1. GDP:​GNAI1:​GNB1-5:​GNG1-5@Cytosol map → map GNAI1:​GTP@Cytosol map + GNB1-5:​GNG1-5@Cytosol map
  2. GDP:​GNAI2:​GNB1-5:​GNG1-5@Cytosol map → map GNAI2:​GTP@Cytosol map + GNB1-5:​GNG1-5@Cytosol map