Identifiers
NAME:I-SMAD*:SMURF*
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
References
PMID:22921829
SMAD7 binds to SMURF1 and SMURF2. The binding involves a PY motif in SMAD7.
PMID:11163210
SMAD7 binds to SMURF2 to form a complex that targets the TGFBR1 for degradation.
PMID:12151385
Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane.
PMID:11278251
Inhibitory Smad7 associates with Smurf1 in the nucleus and is exported to the cytoplasm.
Smad7 thus recruits Smurf1 to TGFBR1, resulting in the degradation and rapid turnover of the TGFBR1 protein.
PMID:21897371
SMAD6 binds to SMURF1 and SMURF2
PMID:15761153
SMAD7, SMURF1, SMURF2, SMAD2, SMAD3 all bind to TGFBR1
Inhibitory Smads (I-Smads) represented by Smad6 and Smad7, negatively regulates TGFB signaling by interacting with the activated TGFBR1
PMID:9335507
Smad7 associates stably with the TGFB receptor complex, but is not phosphorylated upon TGFB stimulation
PMID:9335505
Smad6 is quite different in structure from the other SMAD proteins, and forms stable associations with TGFBR1.
Smad6 interferes with the phosphorylation of Smad2 and the subsequent heteromerization with Smad4, but does not inhibit the activity of Smad3.
Smad6 also inhibits the phosphorylation of Smad1 that is induced by the BMP type IB receptor
PMID:9215638
Smad7 prevents TGFB-dependent formation of Smad2/Smad4 complexes and inhibits the nuclear accumulation of Smad2.
Smad7 interacts stably with the activated TGFBR1, thereby blocking the association, phosphorylation, and activation of Smad2
TGFB rapidly induces expression of Smad7 mRNA, suggesting that Smad7 may participate in a negative feedback loop to control TGFB responses.
Identifiers
NAME:I-SMAD*:SMURF*
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
References
PMID:22921829
SMAD7 binds to SMURF1 and SMURF2. The binding involves a PY motif in SMAD7.
PMID:11163210
SMAD7 binds to SMURF2 to form a complex that targets the TGFBR1 for degradation.
PMID:12151385
Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane.
PMID:11278251
Inhibitory Smad7 associates with Smurf1 in the nucleus and is exported to the cytoplasm.
Smad7 thus recruits Smurf1 to TGFBR1, resulting in the degradation and rapid turnover of the TGFBR1 protein.
PMID:21897371
SMAD6 binds to SMURF1 and SMURF2
PMID:15761153
SMAD7, SMURF1, SMURF2, SMAD2, SMAD3 all bind to TGFBR1
Inhibitory Smads (I-Smads) represented by Smad6 and Smad7, negatively regulates TGFB signaling by interacting with the activated TGFBR1
PMID:9335507
Smad7 associates stably with the TGFB receptor complex, but is not phosphorylated upon TGFB stimulation
PMID:9335505
Smad6 is quite different in structure from the other SMAD proteins, and forms stable associations with TGFBR1.
Smad6 interferes with the phosphorylation of Smad2 and the subsequent heteromerization with Smad4, but does not inhibit the activity of Smad3.
Smad6 also inhibits the phosphorylation of Smad1 that is induced by the BMP type IB receptor
PMID:9215638
Smad7 prevents TGFB-dependent formation of Smad2/Smad4 complexes and inhibits the nuclear accumulation of Smad2.
Smad7 interacts stably with the activated TGFBR1, thereby blocking the association, phosphorylation, and activation of Smad2
TGFB rapidly induces expression of Smad7 mRNA, suggesting that Smad7 may participate in a negative feedback loop to control TGFB responses.
em_emtc_emtc_re1167( EMT Senescence ):
PMID:22286770
The inhibitory Smad7 mRNA is repressed by MIR106B, MIR93, MIR25.
Smad7 antagonizes TGF-b signaling through multiple mechanisms, including binding to TGFBR1 and interfering with recruitment and downstream phosphorylation and activation of Smad2 and Smad3.
Smad7 also functions to recruit E3 ubiquitin ligases to TGRFBR1, resulting in its degradation.
Repression of Smad7 therefore activates TGF-beta signaling.