References
PMID:22921829
SMAD7 binds to SMURF1 and SMURF2. The binding involves a PY motif in SMAD7.
PMID:11163210
SMAD7 binds to SMURF2 to form a complex that targets the TGFBR1 for degradation.
PMID:12151385
Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane.
PMID:11278251
Inhibitory Smad7 associates with Smurf1 in the nucleus and is exported to the cytoplasm.
Smad7 thus recruits Smurf1 to TGFBR1, resulting in the degradation and rapid turnover of the TGFBR1 protein.
PMID:21897371
SMAD6 binds to SMURF1 and SMURF2