Protein IGF1 map

Identifiers
HGNC:5464
insulin like growth factor 1
HUGO:IGF1 hgnc_id:HGNC:5464 HGNC:5464 ENTREZ:3479 UNIPROT:P05019
insulin-like growth factor 1 (somatomedin C)
HUGO:IGF1 HGNC:5464 ENTREZ:3479 UNIPROT:P05019
HUGO:IGF1

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

References
PMID:17145802
CASCADE:TGFB
PMID:11237532 ; PMID:19631971
In breast cancers, both IGF-I and IGF-II
are expressed in the stromal ???broblasts and expression
of IGF-II in particular correlates with tumor progression
PMID:12181198
IGF-I potently stimulated proliferation of TGF-??1-activated myofibroblasts without reversing activated fibrogenic phenotype. We conclude that TGF-??1 and IGF-I both stimulate type I collagen synthesis but have differential effects on activated phenotype and proliferation.
TGF-??1 induces IGF-I expression in CCD-18Co fibroblast cells.

Modifications:
In compartment: Cytosol
  1. IGF1@Cytosol map
In compartment: Extracellular Matrix
  1. IGF1@Extracellular Matrix map
In compartment: Extracellular space
  1. IGF1@Extracellular space map
In compartment: Membrane
  1. IGF1@Membrane map
In compartment: default
  1. IGF1@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. IGF1@Extracellular Matrix map → map IGF1/2*@Extracellular Matrix map
    2. IGF1@Cytosol map → map IGF1@default map
    3. rIGF1@Cytosol map → map IGF1@Cytosol map
    4. IGF family*@Extracellular space map → map IGF1@Extracellular space map
    As Catalyser:
    1. IGF1R@Cytosol map → map IGF1R|​pho@Cytosol map
    2. IGF1R@Membrane map → map IGF1R|​pho@Membrane map