Protein WASF2 map

Identifiers
WAS protein family, member 2
HUGO:WASF2 HGNC:12733 ENTREZ:10163 UNIPROT:Q9Y6W5

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map

References
PMID:21383498
 NATURAL_KILLER  map
CASCADE:IL2
IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function.

WASF2@Cytosol

References
em_emtc_emtc_re789( EMT Senescence  map ):
Rac1 binds to BAIAP2 which in turn associates with WASF2.
This stimulates ARP2/3 and leads to actin cytoskeleal polymerization.
PMID:16702231
WAVE2 (so-called WASF2) activates the ARP2/3 complex for Rac-induced actin polymerization during lamellipodium formation
PMID:9843499
WASF (WAVE) as regulator of actin reorganization downstream of Rac.
Expressed WAVE induces the formation of actin filament clusters.
WAVE plays a critical role downstream of Rac in regulating the actin cytoskeleton required for mem- brane ruffling
PMID:12054568
WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac.
em_emtc_emtc_re791( EMT Senescence  map ):
PMID:8625410
PMID:16293614
PMID:10467124
PMID:10511705
CDC42 induces actin cytoskeleton changes by activating WASP and N-WASP.
WASP and N-WASP binds to ARP2/3 and this lieads to actin cytoskeletal polymerization and filopodia formation.
PMID:14749719
PAK1 phosphorylates and activates ARP2_3 complex.

Modifications:
In compartment: Cytosol
  1. WASF2@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. WASF2@INNATE_IMMUNE_CELL_Cytosol map
  2. WASF2|​pho@INNATE_IMMUNE_CELL_Cytosol map
In compartment: T_cell
  1. WASF2@T_cell map
  2. WASF2|​pho@T_cell map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. WASF2@T_cell map → map WASF2|​pho@T_cell map
    2. WASF2@Cytosol map → map WASF2@Cytosol map
    3. WASF2@Cytosol map + Actin cytoskeletal*@Cytosol map → map em_emtc_emtc_s2995
    4. WASF2@INNATE_IMMUNE_CELL_Cytosol map → map WASF2|​pho@INNATE_IMMUNE_CELL_Cytosol map
    As Catalyser:
    1. Actin cytoskeletal*@T_cell map → map Actin cytoskeletal*|​hm2@T_cell map
    2. ARP2_3*@Cytosol map → map ARP2_3*@Cytosol map
    3. Actin cytoskeletal*@INNATE_IMMUNE_CELL_Cytosol map → map Actin cytoskeletal*|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol map