Protein PTK6 map

Identifiers
protein tyrosine kinase 6
HUGO:PTK6 HGNC:9617 ENTREZ:5753 UNIPROT:Q13882

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map

References
PMID:18829532
PTK6 phosphorylates ARHGAP35
RasGAP actvity of RASA1 is reduced when associated with ARHGAP35 which is a specific GAP for RhoA
ARHGAP35 is tyrosine-phosphorylated.
The association of ARHGAP35 (p190) with RASA1 (p120) is promoted and stabilized by phosphorylation of p190 at Y1105 by CSK or by PTK6.

PTK6@Cytosol

References
em_emtc_emtc_re931( EMT Senescence  map ):
PMID:18829532
PMID:9819392
PTK6 and CSK both can phosphorylate ARHGAP35 (p190) at Y1105
RasGAP actvity of RASA1 is reduced when associated with ARHGAP35 which is a specific GAP for RhoA
ARHGAP35 is tyrosine-phosphorylated.
The association of ARHGAP35 (p190) with RASA1 (p120) is promoted and stabilized by phosphorylation of p190 at Y1105 by CSK or by PTK6.

Modifications:
In compartment: Cytosol
  1. PTK6@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
      As Catalyser:
      1. ARHGAP35@Cytosol map → map ARHGAP35|​pho@Cytosol map