Protein IHH map

Identifiers
indian hedgehog
HUGO:IHH hgnc_id:HGNC:5956 HGNC:5956 ENTREZ:3549 UNIPROT:Q14623

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / GROWTH_FACTORS_SIGNALING_PATHWAYS  map

References
CASCADE:HH
PMID:18754008
CAFs respond to Hh stimulation by increasing the production of ECM.
Stromal hedgehog signalling can support tumour growth.
subsets of colorectal, endometrial, ovarian and pancreatic cancers overexpressed Hh ligand mRNA (data not shown). Quantitative polymerase chain reaction with reverse transcription (RT???PCR) profiling of an independent set of human tissue specimens confirmed that the transcript levels of SHH and/or Indian hedgehog homologue (IHH) ligands were significantly upregulated in subsets of these cancers.

Modifications:
In compartment: default
  1. IHH@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
      As Catalyser:
      1. PTCH*:​SMO@Cytosol map → map SMO@Cytosol map + PTCH*@Cytosol map