Protein SLC16A4 map

Identifiers
solute carrier family 16 member 4
HUGO:SLC16A4 hgnc_id:HGNC:10925 HGNC:10925 ENTREZ:9122 UNIPROT:O15374

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / METABOLIC  map

References
PMID:22850421
CAFs have increased anaerobic glycolysis, as revealed by their increased basal glucose uptake
CAFs show increased expression of MCT4 (SLC16A4), the passive lactate-proton symporter driving lactate efflux, thereby validating the idea that prostate CAFs increased their lactate production with respect to healthy HPFs.
Protein level of MCT4 (SLC16A4) in CAFs is redox and HIF1 dependent.
PMID:24486645
Catabolic cancer-associated fibroblasts enriched by MCT4 transfer energy and biomass to anabolic cancer cells, fueling tumor growth.
PMID:23907124
Loss of Cav-1 in the stroma and gain of monocarboxylate transporter 4 (MCT4) expression in the stroma have been found to be involved in the progression of DCIS to IDC

Modifications:
In compartment: Cytosol
  1. SLC16A4@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rSLC16A4@Cytosol map → map SLC16A4@Cytosol map
    As Catalyser:
    1. lactate@Cytosol map → map lactate@default map