Protein SIX1 map

Identifiers
SIX homeobox 1
HUGO:SIX1, HGNC:10887, ENTREZ:10887, UNIPROT:Q15475, GENECARDS:GC14M061111

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map

References
Homeoprotein Six1 increases TGF-beta type I receptor and converts TGF-beta signaling from suppressive to supportive for tumor growth.
PMID:19726885
PMID:22286770

SIX1@Nucleus

References
em_emtc_emtc_re356( EMT Senescence  map ):
PMID:22945800
PMID:22286765
Six1 induces ZEB1 and EMT through transcriptional repression of miR200.
PMID:20706219
Feedback loop between ZEB1, ZEB2 and MIR200 family
PMID:19935649
ZEB1 inhibits expression of MIR200 family
PMID:22514743
SNAI1 represses expression of all MIR200 family members.
em_emtc_emtc_re362( EMT Senescence  map ):
PMID:22286770
miR-106b, miR-93 and miR-25 are overexpressed in Six1 transgenic mammary glands as compared with control mammary

Modifications:
In compartment: Nucleus
  1. SIX1@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
      As Catalyser:
      1. gMIR200*@Nucleus map → map arMIR200*@Nucleus map
      2. gMIR106B_25*@Nucleus map → map arMIR106B_25*@Nucleus map