Protein PTPN2 map

Identifiers
HUGO:PTPN2

Maps_Modules
MODULE:MACROPHAGE
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS

References
PMID:19833085, PMID:15699106, PMID:12138178
Inactivation of nuclear STAT1 occurs rapidly following binding to chromatin and activation of target gene transcription.
Subsequently STAT1 is dephosphorylated by phosphatases such as PTPN2 (TCP45) and PTPN11 (SHP2), and dephosphorylated STAT1
returns to cytoplasm, where it can potentially serve as the substrate for subsequent rounds of activation and inactivation.
PMID:19833085
Probably, acetylation of STAT1 on lysine residues 410 and 413 in the nucleus results in enhanced interaction with TCP45 (PTPN2) and increased dephosphorylation

PTPN2@Cytosol

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol
  1. PTPN2@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
      As Catalyser:
      1. STAT1|​pho|​ace@Cytosol map → map STAT1|​ace@Cytosol map
      2. STAT1|​pho|​active@Cytosol map → map STAT1@Cytosol map