Protein SLC7A11
MODULE:MACROPHAGE
MODULE:MDSC
MODULE:NO_ROS_PRODUCTION
HUGO:SLC7A11
PMID:20414655, PMID:2880923, PMID:3115975, PMID:20028852
Macrophages import cystine through their x c ??? transporter, reduce it to cysteine and then export the cysteine through their ASC neutral amino acid transporter.
PMID:20028852
MDSCs express the cystine transporter but lack cystathionase and the ASC neutral amino acid transporter
Therefore, macrophages, DCs, and MDSCs can import cystine; however, unlike macrophages and DCs, MDSCs are unable to export cysteine.
MDSC sequester cystine and prevent T cells from obtaining cysteine which is important for Tcell activation.

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Modifications:
In compartment: Membrane

1. SLC7A11@Membrane

Participates in complexes:
In compartment: Membrane

1. SLC3A2:​SLC7A11@Membrane

Participates in reactions:
As Reactant or Product:

1. SLC3A2@Membrane + SLC7A11@Membrane → SLC3A2:​SLC7A11@Membrane

As Catalyser:

1. Cystine@default → Cystine@Cytosol