Protein HIF2A* map

Identifiers
HUGO:EPAS1

Maps_Modules
MODULE:MACROPHAGE
MODULE:RECRUITMENT_OF_IMMUNE_CELLS

References
PMID:20194441
HIF2a expression is assosiated with M2 phenotype.
PMID:11888900, PMID:20644254
HIF2A induces tumor growth and angiogenesis.
PMID:16127144
HIF-1A and HIF-2A are up-regulated by human macrophages exposed to hypoxia??in vitro??and by TAMs in hypoxic/necrotic areas of human tumors
PMID:20644254
HIF2a induces macrophage migration via upregulation of CXCR4, FN1 expression and upregulation of M-CSFR protein level.

HIF2A*@Cytosol

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol
  1. HIF2A*@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rHIF2A*@Cytosol map → map HIF2A*@Cytosol map
    2. HIF2A*@Cytosol map → map HIF2A*@Cytosol map
    3. HIF2A*@Cytosol map → map degraded
    As Catalyser:
    1. rCSF1R@Cytosol map → map CSF1R@Membrane map
    2. gCXCR4@Cytosol map → map rCXCR4@Cytosol map
    3. gFN1@Cytosol map → map rFN1@Cytosol map
    4. gVEGFR1*@Cytosol map → map rVEGFR1*@Cytosol map