Protein EGLN1 map

Identifiers
HUGO:EGLN1

Maps_Modules
MODULE:MACROPHAGE
MODULE:RECRUITMENT_OF_IMMUNE_CELLS

References
PMID:21765015
The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex.

EGLN1@Cytosol

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol
  1. EGLN1@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
      As Catalyser:
      1. HIF1A@Cytosol map → map degraded