Identifiers
HUGO:CXCL8
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CYTOKINES_CHEMOKINES_PRODUCTION
EMT Senescence / EMT_REGULATORS
EMT Senescence / SENESCENCE
References
PMID:15079071 PMID:27557510
CASCADE:IL1
CASCADE:TNF
PMID:21847358
IL-1?? was established as the initiator of the enhanced production of inflammatory factors through the binding of IL-1?? to IL-1 receptor 1 (IL-1R1) expressed predominantly by CAFs.
IL1A upregulates expression of IL6, CCL20, CXCL8, COX2 in CAFs.
IL-1?? Expression Levels in prostate cancer Tissue Correlated to Poor Clinical Outcome
PMID:17916596
In vitro analyses
revealed a striking induction of IL-8 expression in CAFs
and LFs by tumor necrosis factor-alpha (TNFA). The effect
of TNFA on CAFs is inhibited by the nuclear factor-kB
inhibitor parthenolide.
PMID??:??26548401
miR-302c was found to inhibit IL-8 expression and restrain tumor invasion and metastasis.
PMID:18555778
In response to oncogenic stress, both IL6 and IL8 genes were activatedbythe transcription factorC/EBPb,upon its recruitment to either promoter.