Identifiers
HUGO:IL13
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CYTOKINES_CHEMOKINES_PRODUCTION
Innate Immunity / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
Innate Immunity / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
References
PMID:26755705
PMID:20184663
CAFs may also directly influence the polarization of macrophages toward an M2 phenotype: IL-13, one of the key cytokines driving M2-like polarization of macrophages, was shown to be secreted by CAFs
PMID:12401408
IL13 is assosiated with M2 phenotype of macrophages
PMID:14610620, PMID:12223527
IL13 acts via IL4 receptor type 2, which contains two subunits IL4R and IL13RA1
PMID:14610620
Other receptor of IL13 is IL13RA2
PMID:18451175, PMID:14657224
IL13 signaling via IL13RA2 induces TGFB production in MDSC.
PMID:18250477
IL-4 or IL-13 stimulated the release of galectin-3
into the culture media in both BMDMs and PBMs.
PMID:21097505
IL-13 upregulates expression of SOCS1
PMID:9535722
IL13 induces phosporylation of IRS2 and PLCG1 which is probably a PLC responsible for downstream IL13 dependent Ca2+??mobilization signaling and assosiation of IRS2 and PLCG1
PMID:15099563
Mast cells produce cytokines TNF-a, TGF-b, IFN-a, IL-1a, IL-1b, IL-5, IL-6,
IL-13, IL-16, IL-18