Identifiers
HUGO:PRF1
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
References
PMID:19380804
NATURAL_KILLER
CASCADE:IL12
CASCADE:IL2
CASCADE:IL15
CASCADE:IFNAB
PMID:9841920
Induction of perforin mRNA by IL-2 and IL-15 was markedly decreased in Stat5b???/??? splenocytes
PMID:21960590
Human miR-27a* specifically bound to the 3' untranslated regions of Prf1 and GzmB, down-regulating expression in both resting and activated NK cells.
PMID:22649192
miR-378 and miR-30e suppress IFN-?????upregulated granzyme B and perforin expression in human NK cells.
miR-378 and miR-30e are markedly decreased in activated NK cells by IFNA,
miR-378 and miR-30e directly targeted granzyme B and perforin, respectively and suppress of human NK cell cytotoxicity.
PMID:24698324
miR-150 binds to 3' untranslated regions of mouse and human Prf1, posttranscriptionally downregulating its expression.
PMID:15084276
T-bet is a key factor in the terminal maturation and peripheral homeostasis of NK and V??14i NKT cells.
Granzyme B, perforin and Runx1 are direct and positievly regulated targets of TBX21 (T-BET) in NK cells.