Protein PDL1* map

Identifiers
HUGO:CD274

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / INHIBITING_CHECKPOINTS  map
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CYTOKINES_CHEMOKINES_PRODUCTION  map

References
PMID:24076050 PMID:12538684 PMID:18585785 PMID:17629517
PMID:26201938
CAFs expressed the co-regulatory molecules, B7H1 (PDL1) and B7DC (PDL2), whereas NFs (normal fibroblasts) did not.
 DENDRITIC_CELL  map
PMID:24076050, PMID:12538684
PDL1 and PDL2 are expressed in DCs.
blockade of PD-L2 on dendritic cells results in enhanced T cell proliferation and cytokine production, including that of IFN-gamma and IL-10, while blockade of PD-L1 results in similar, more modest, effects. Blockade of both PD-L1 and PD-L2 showed an additive effect. Both whole mAb and Fab enhanced T cell activation, showing that PD-L1 and PD-L2 function to inhibit T cell activation.

Modifications:
In compartment: Cancer_cell
  1. PDL1*@Cancer_cell map
In compartment: T_cell
  1. PDL1*@T_cell map
Participates in complexes:
In compartment: T_cell
  1. CD80:​PDL1*@T_cell map
Participates in reactions:
As Reactant or Product:
  1. PDL1*@T_cell map + CD80@Cancer_cell map → map CD80:​PDL1*@T_cell map
  2. Ligands_of_Inhibiting_immune checkpoints@Cancer_cell map → map PDL1*@Cancer_cell map
As Catalyser:
  1. PDCD1@T_cell map + PTPN11@T_cell map + PTPN6@T_cell map → map PDCD1:​PTPN11:​PTPN6@T_cell map