Identifiers
HUGO:IL10
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:TUMOR_PROMOTING_INFLAMMATION
Innate Immunity / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
References
PMID:16200688 PMID:15282297 PMID:26755705 PMID:12818165
PMID:20184663
Production of cytokines, chemokines and growth factors showed a significant increase in TAFs for vascular endothelial growth factor, transforming growth factor-beta1, interleukins (IL-4, IL-10) and tumour necrosis factor alpha.
PMID:21115385
IL10 is immunosuppressive cytokine.
PMID:10623821, PMID:10623821
IL10??? ??? expression in macrophages is assosiated
with TAM (M2) phenotype.
PMID:10542212
IL10??? ??? promotes M2??? ???phenotype of macrophages
trough suppression of??? ???NFkB signaling
and inhibition of synthesis of pro-inflammatory cytokines.
PMID:11875494
IL10 stimulates HO1 expression via MAPK p38 stimulation.
PMID:16713974, PMID:14607900
IL10 and Stat3 mediate feedback inhibition of TLR signaling. TLR2/TLR4 induces
IL10 expression. IL10 inhibits exppression of TNF downstream of TLR.
PMID:16713974
Production of IL10 is partially ERK dependent.
PMID:21191065
regulatory effect of galectin-1 is mediated, in part, through its ability to induce, in an Id3 (inhibitor of DNA binding 3)-dependent manner, the expression of IL-10 in monocytes and MdDCs.
At the same tyme IL10 siglaning also participates in ID3 upregulation via PI3K/AKT pathway
PMID:17404308
CSF1 induces IL10 and CCL2 mRNA expression in macrophages
PMID:9834059
NK cells stimulated by IL12 induces IL10 production.
PMID:11207245
IFNA induces IL10 production in Dcs (negative loop)
PMID:21220452
that IL-10 increased??March1??mRNA by approximately six fold
PMID:15579430
Metastatic Melanoma Secreted IL-10 Down-Regulates CD1(CD1a, CD1b, CD1c, and CD1d) protein Molecules on Dendritic Cells in Metastatic Tumor Lesions (
PMID:16424049
IFNG induces INOS and IL10 expression and TGFB secretion in MDSC