Protein TRAFs* map

Identifiers
HUGO:TRAF1 HUGO:TRAF2 HUGO:TRAF3 HUGO:TRAF4 HUGO:TRAF5 HUGO:TRAF6

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / ACTIVATING_CHECKPOINTS  map

References
PMID:23758787

TRAFs*@T_cell

References
ad_re400( Adaptive Immune Response  map ):
PMID:14660645, PMID:18264787, PMID:11460167
Activated TAK1 phosphorylates IKK-beta proteins
leading to activation of NF-??B downstream of HMGB1.
PMID:21232017, PMID:21133840, PMID:17301840
PMID:24958845, PMID:24699077
The LUBAC complex ubiquitinates NEMO, a subunit of the IKK complex downstream of TNF and upregulates IkBa degradetion.
PMID:11280761
VEGF signaling blocs TNF-?? induced activation of I??B kinase (IKK complex).This decreased IKK activation correlated with the inhibition of I??B?? phosphorylation and degradation of I??B?? and I??B?? in HPCs, and this inhibition is inhdependent or FLT1 and KDR

Modifications:
In compartment: T_cell
  1. TRAFs*@T_cell map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. TRAFs*@T_cell map → map TRAFs*@T_cell map
    As Catalyser:
    1. ERK1/2*@T_cell map → map ERK1/2*|​pho@T_cell map
    2. IKBKG:​IKK_alpha_*:​IKK_beta_*@T_cell map → map IKBKG|​ubi:​IKK_alpha_*:​IKK_beta_*|​pho@T_cell map