Protein CBL map

Identifiers
HUGO:CBL

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
PMID:11353765
 NATURAL_KILLER  map
CASCADE:SLAMF7
CASCADE:2B4
CASCADE:NKG2D
PMID:20189481, PMID:18835194
CBL inhibited Vav1-dependent activation signals in NK via VAV1 ubiquitination.
Tyrosine phosphorylation of c-Cbl was detected after stimulation NKL cells by either NKG2D, 2B4, or the synergistic NKG2D and 2B4 combination.
Cbl Limits NK Cell Activation.
PMID:15169881
2B4 signaling induces phosphorylation of SHIP1,VAV1,CBL.
This phosphorylation is dependent on SAP and FYN.

Modifications:
In compartment: T_cell
  1. CBL@T_cell map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
      As Catalyser:
      1. CD247|​pho:​CD3*|​pho:​ZAP70:​alpha_/beta_TCR*@cSMAC map → map CD247|​pho|​ubi:​CD3*|​pho:​ZAP70:​alpha_/beta_TCR*@cSMAC map