Protein MAP2K3 map

Identifiers
HUGO:MAP2K3
mitogen-activated protein kinase kinase 3
HUGO:MAP2K3 HGNC:6843 ENTREZ:5606 UNIPROT:P46734
PRKMK3

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / MAPK  map

References
PMID:24104473 PMID:16799472 PMID:11371360 PMID:15735649
synonym:MKK3 synonym:MEK3
CASCADE:INTEGRIN_A4B1
CASCADE:INTEGRIN_A5B1
CASCADE:TLR2_4
PMID:10661401
MKK3 is activated by ??1 Integrin Cross-Linking on Human NK Cells,
It activates p38MAPK regulated IL8 production by NK cells downstream of integrin signaling.
PMID:9379049
MKK3 and MKK4 are capable of phosphorylating p38mapk in macrophages,
downstream of TNF/Tnf receptor signaling.
MAP2K for P38 pathway. MEK3 is more strongly activated by physical and chemical stresses than by other stimuli.
PMID:11274345

Modifications:
In compartment: T_cell
  1. MAP2K3@T_cell map
  2. MAP2K3|​pho@T_cell map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. MAP2K3@T_cell map → map MAP2K3|​pho@T_cell map
    As Catalyser:
    1. p38*@T_cell map → map p38*|​Tyr180_pho|​TYR182_pho|​active@T_cell map