Identifiers
HUGO:MAP2K4
mitogen-activated protein kinase kinase 4
HUGO:MAP2K4 HGNC:6844 ENTREZ:6416 UNIPROT:P45985
SERK1
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / STARVATION_AUTOPHAGY
Regulated Cell Death / CASPASES
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / MOMP_REGULATION
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
References
PMID:16076871
PMID:24104473 PMID:16799472 PMID:15735649
synonym:MKK4 synonym:MEK4
MACROPHAGE
CASCADE:TLR2_4
PMID:10465784
ECSIT (evolutionarilyconserved signaling intermediate inToll pathways), is specific for the Toll/IL-1 pathways and is a regulator of MEKK-1 processing. Expression of wild-type ECSIT accelerates processing of MEKK-1, whereas a dominant-negative fragment of ECSIT blocks MEKK-1 processing and activation of NF-??B
ECSIT mutant also strongly inhibited MEKK-1 activation of AP-1 (probably via MAP2K4/JNK),
additionally TRAF6-induced signaling is inhibited by dominant-negative constructs of MEKK-1.
PMID:17379190
MEK4/JNK/AP-1 path way is active in mactophages downstream of TLR4,
and induces iNOS expression.
PMID:15170913, PMID:9582321, PMID:11668179
MEKK1 --> SEK1/MKK4 --> p38 mitogen-activated protein kinase pathway upregulates COX2 expression and PGE2 production in macrophages,
via activation of transcription factor C/EBP beta.
MAP2K for JNK pathway. MEK4 is weakly activated by TNF and IL-1.
PMID:11274345
References
ad_re361:( Adaptive Immune Response ) PMID:16713974 PMID:11438547 PMID:24378531