Protein B2M map

Identifiers
HUGO:B2M

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / SMAC  map

References
PMID:16181333 PMID:22076556 PMID:10358761
 DENDRITIC_CELL  map
PMID:16181333, PMID:22076556
Upon dissociation from CNX, the heavy chain of (MHC) class I binds ??2 microglobulin (b2m) and is incorporated into the peptide-loading complex.
PMID:10358761
All CD1 proteins studied to date are expressed on the surface of cells as type I transmembrane proteins that associate noncovalently with ??2-microglobulin
PMID:11717192
The gene expression of TAP1, TAP2, tapasin, ??2m and HLA-?? HC is up-regulated in mature DC.

Modifications:
Participates in complexes:
In compartment: Cancer_cell
  1. B2M:​MHC_class_I*:​Tumor_antigen_fragment@Cancer_cell map
Participates in reactions:
As Reactant or Product:
  1. TCR_signaling_induction@Cancer_cell map → map B2M:​MHC_class_I*:​Tumor_antigen_fragment@Cancer_cell map
As Catalyser:
  1. LCK@cSMAC map + CD8*@cSMAC map → map CD8*:​LCK|​Y394_pho@cSMAC map
  2. CD247:​CD3*:​alpha_/beta_TCR*@cSMAC map → map CD247|​pho:​CD3*|​pho:​alpha_/beta_TCR*@cSMAC map + PTPRC@dSMAC map