Protein PVR map

Identifiers
HUGO:PVR

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / INHIBITING_CHECKPOINTS  map
 Innate Immunity  map  / INTEGRINS  map

References
PMID:22285893 PMID:12913096 PMID:19098271
 NATURAL_KILLER  map
CASCADE:LFA1
PMID:16730454PMID:16730454, PMID:24343663, PMID:18657862
DNAX accessory molecule-1 (DNAM-1, CD226) isa cell surface molecule capable of enhancing cytolytic activity and cytokine production in NK cells. Its ligands represented by two members of the nectin family: the poliovirus receptor (PVR CD155) and nectin-2 (CD112) [64]. Both molecules can be highly expressed in tumor cell lines, including carcinomas, melanomas and neuroblastomas.
Level of CD155 and CD112 expression on neuroblastoma cells derived from human patients correlated with their susceptibility to NK cellmediated killing
PMID:19801517
Coincubation of NK cells with ovarian carcinoma cells expressing the DNAM-1 ligand CD155 led to reduction of DNAM-1 expression.

Modifications:
In compartment: Cancer_cell
  1. PVR@Cancer_cell map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. Ligands_of_Inhibiting_immune checkpoints@Cancer_cell map → map PVR@Cancer_cell map
    As Catalyser:
    1. TIGIT@T_cell map → map TIGIT@T_cell map
    2. CD96@T_cell map → map CD96@T_cell map
    3. CD226@T_cell map → map CD226|​pho|​active@T_cell map