Identifiers
HUGO:IL4
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / CYTOKINES_CHEMOKINES_PRODUCTION
Innate Immunity / IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
Innate Immunity / IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS
References
PMID:11160275 PMID:11371360 PMID:1825141 PMID:2965306 PMID:12818165
PMID:20184663
CAFs may also directly influence the polarization of macrophages toward an M2 phenotype: IL-4, one of the key cytokines driving M2-like polarization of macrophages, was shown to be secreted by CAFs
PMID:12401408
IL4 is assosiated with M2 polarization of macrophages
PMID:23124025, PMID:20856220
In human monocytes, IL-4 mediates its effect through the
type I IL-4R, composed of the IL-4R????and common gamma-chain (IL-2R??);
And, probably through type II IL-4Ris composed of the
IL-4Ra chain and IL-13Ra1
PMID:12496409
Arg1 is up-regulated in MDSC by IL-4.
Arg1 increases superoxide production in myeloid cells through a pathway that likely utilizes the reductase domain of inducible NO synthase (iNOS), and that superoxide is required for Arg1-dependent suppression of T cell function.
PMID:18250477
LIL-4 or IL-13 stimulated the release of galectin-3
into the culture media in both BMDMs and PBMs.
PMID:11870632, PMID:9834059
Stimulation of??NK??cells??with IL-4 inhibited IFN-gamma, but increased IL5, IL-13 production.
NK cells stimuletad by IL4 have NK2 subtype ()