Identifiers
elastin microfibril interfacer 2
HUGO:EMILIN2 hgnc_id:HGNC:19881 HGNC:19881 ENTREZ:84034 UNIPROT:Q9BXX0
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / MATRIX_REGULATION
References
PMID:22179046
MiR-320 is a Pten target in fibroblasts that suppresses tumor growth
Ets2 is a direct target of miR-320 in fibroblasts
Mmp9 and Emilin2 (Elastin Microfibril Interfacer 2) are directly regulated by miR-320 via their 3??? UTR target sequences
PMID:20360940
EMILIN2 is an extracellular matrix (ECM) glycoprotein, triggers cell death through a direct binding to death receptors.
using either the full molecule or the active fragment, for the first time, we demonstrate a significant antitumoral effect in vivo, likely due to a decrease in tumor cell viability. Unexpectedly, tumors treated with EMILIN2 or the deletion mutant display a significant increase of tumor angiogenesis.