Identifiers
HUGO:MMP1
matrix metallopeptidase 1 (interstitial collagenase)
HUGO:MMP1, HGNC:7155, ENTREZ:4312, GENECARDS:GC11M102660, UNIPROT:P08254
CLG, "matrix metalloproteinase 1 (interstitial collagenase)"
HUGO:MMP1 HGNC:7155 ENTREZ:4312 UNIPROT:P03956 GENECARDS:MMP1 REACTOME:59385 KEGG:4312 ATLASONC:GC_MMP1 WIKI:MMP1
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / ECM
HMC:TUMOR_PROMOTING_INFLAMMATION
Innate Immunity / TUMOR_GROWTH
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / WNT_NON_CANONICAL
References
PMID:20015200
Tissue factor pathway inhibitor-2 (TFPI-2) is a potent inhibitor of plasmin which activates matrix metalloproteinases (MMPs) involved in degradation of the extracellular matrix. Its secretion in the tumour microenvironment makes TFPI-2 a potential inhibitor of tumour invasion and metastasis
TFPI-2 down-regulation enhanced cell adhesion to collagen IV and laminin via an increase in ??(1) integrin on cell surface, and increased MMP expression (mainly MMP-1 and -3) contributing to cancer cell invasion through basement membrane components.
MACROPHAGE
PMID:22880008
Classical activation of macrophages derived in vitro from un-fractionated CD16(+/-) or negatively-selected CD16(-) macrophages up-regulated MMP-1, -3, -7, -10, -12, -14 and -25 and decreased TIMP-3 steady-state mRNA levels.
By contrast, alternative activation decreased MMP-2, -8 and -19 but increased MMP -11, -12, -25 and TIMP-3 steady-state mRNA levels. Up-regulation of MMPs during classical activation depended on mitogen activated protein kinases, phosphoinositide-3-kinase and inhibitor of ??B kinase-2. Effects of interferon?? depended on janus kinase-2.
Secreted by stroma cells
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / ECM
References
PMID:22349261
References
s_wnc1_re7( Survival ):
PAR1 is activated by cleavage of exodomain at Arg41-Ser42
PMID:14652070
PAR1 can be activated by MMP1
PMID:15707890