Protein GLI3 map

Identifiers
HUGO:GLI3

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / GROWTH_FACTORS_SIGNALING_PATHWAYS  map

References
CASCADE:HH
PMID:17638910
GLI1, GLI2, GLI3 proteins are expressed in fibroblasts, GLI1 and GLI2 expression is upregulated by TGFB via SMAD3
PMID:19081070; PMID:22354771
The vertebrate GliRepressor function is largely derived from Gli3 while the primary GliActivator activity is largely contributed by Gli2. Gli1 is a transcriptional target of Hh signaling and acts as a transcriptional activator to reinforce GliA function

Modifications:
In compartment: Cytosol
  1. GLI3@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rGLI3@Cytosol map → map GLI3@Cytosol map
    As Catalyser: