Protein TFAM map

Identifiers
HUGO:TFAM
transcription factor A, mitochondrial
HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CAF_INHIBITION_ANTITUMOR  map
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / MITOCHONDRIAL_GENES  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map

References
_INHIBITION_ANTITUMOR
PMID:22129993
TFAM is mitochondrial transcription factor A, which is important in functionally maintaining the mitochondrial respiratory chain. Interestingly, TFAM-deficient fibroblasts showed evidence of mitochondrial dysfunction and oxidative stress, with the loss of certain mitochondrial respiratory chain components, and the over-production of hydrogen peroxide and L-lactate.
TFAM-deficient fibroblasts also showed a loss of caveolin-1 (Cav-1), a known breast cancer stromal biomarker.

TFAM@Mitochondrial Matrix

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / MITOCHONDRIAL_GENES  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map

References
rc_re1050:( Regulated Cell Death  map ) PMID:17662942

Modifications:
In compartment: Cytosol
  1. TFAM@Cytosol map
In compartment: Mitochondrial Matrix
  1. TFAM@Mitochondrial Matrix map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. TFAM@Cytosol map → map NEGATIVE_REGULATORS OF_CAF@Cytosol map
    2. TFAM@Cytosol map → map ROS production@Cytosol map
    3. rTFAM@Nucleus map → map TFAM@Mitochondrial Matrix map
    As Catalyser:
    1. rCAV1@Cytosol map → map CAV1@Cytosol map
    2. gMT-DNA*@Mitochondrial Matrix map → map rheavy strand transcript*@Mitochondrial Matrix map
    3. gMT-DNA*@Mitochondrial Matrix map → map rlight strand transcript*@Mitochondrial Matrix map