Protein GPT2 map

Identifiers
HUGO:GPT2
glutamic pyruvate transaminase (alanine aminotransferase) 2
HUGO:GPT2 HGNC:18062 ENTREZ:84706 UNIPROT:Q8TD30

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / METABOLIC  map
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE  map

References
CASCADE:TGFB
CASCADE:PDGF
PMID:25732824
the expression of ALT2 (GPT2) was significantly increased in induced CAFs (Figure 4C), suggesting that the slight elevation of alpha-KG is likely through the glutamate pathway by feedback upregulation of ALT2 in CAFs and fibroblasts with IDH3?? knockdown.
ALT2 is upregulated downstream of TGFB and PDGF.

GPT2@Mitochondrial Matrix

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE  map

Modifications:
In compartment: Cytosol
  1. GPT2@Cytosol map
In compartment: Mitochondrial Matrix
  1. GPT2@Mitochondrial Matrix map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rGPT2@Cytosol map → map GPT2@Cytosol map
    2. GPT2@Mitochondrial Matrix map → map GPT*@Mitochondrial Matrix map
    As Catalyser:
    1. Glutamate@Cytosol map → map Alpha_ketoglutarate@Cytosol map