Protein GLS map

Identifiers
HUGO:GLS
glutaminase
HUGO:GLS HGNC:4331 ENTREZ:2744 UNIPROT:O94925

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / GLUTAMINE_METABOLISM  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE  map
 RECON2  map

References
MODULE METABOLIC
PMID:25002027
SQSTM1 (p62) p62
We also observed a decrease in the direct conversion of [U-13C5] glutamine to glutamate in p62 KO fibroblasts, with a relative increase in the fraction of glutamate derived from [1,2-13C2]glucose
and reduced levels of the glutamine transporters SLC7A5 and SLC1A5, as well as glutaminase-1 (GLS1) (Figure 4O), a critical enzyme in the pathway that catalyzes the conversion of glutamine into glutamate

GLS@Mitochondrial Matrix

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / GLUTAMINE_METABOLISM  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE  map

References
rc_re756( Regulated Cell Death  map ):
PMID:19219026
in human P-493 B lymphoma cells
in human PC3 prostate cancer cells
rc_re750( Regulated Cell Death  map ):
PMID:10048485
by GLS
PMID:10620514
by GLS2
PMID:19894115
in neuroblastomas, localization to mitochondria

Modifications:
In compartment: Cytosol
  1. GLS@Cytosol map
In compartment: Mitochondrial Matrix
  1. GLS@Mitochondrial Matrix map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rGLS@Cytosol map → map GLS@Cytosol map
    2. rGLS@Nucleus map → map GLS@Mitochondrial Matrix map
    As Catalyser:
    1. glutamine@Cytosol map → map Glutamate@Cytosol map
    2. L-glutamine@Mitochondrial Matrix map → map L-glutamate@Mitochondrial Matrix map + NH3@Mitochondrial Matrix map