Protein SCO2 map

Identifiers
SCO2 cytochrome c oxidase assembly protein
HUGO:SCO2 HGNC:10604 ENTREZ:9997 UNIPROT:O43819

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / MITOCHONDRIAL_GENES  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE  map

SCO2@Mitochondrial inner membrane

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / MITOCHONDRIAL_GENES  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE  map

References
rc_re1111( Regulated Cell Death  map ):
PMID:15229189
SCO1, SCO2, and COX17 act cooperatively to load MT-CO2 with copper (copper chaperones)
PMID:19393246
in Hela, COX17 siRNA interferes with copper loading into MT-CO2
PMID:18458339
detailed description of COX17 mediated copper loading of SCO proteins, and interactions with the disulfide based modifications of these proteins

Modifications:
In compartment: Mitochondrial inner membrane
  1. SCO2@Mitochondrial inner membrane map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rSCO2@Nucleus map → map SCO2@Mitochondrial inner membrane map
    As Catalyser:
    1. MT-CO2@Mitochondrial inner membrane map + Cu2+@Mitochondrial inner membrane map → map Cu2+:​MT-CO2@Mitochondrial inner membrane map