References
HUGO:AREG
MODULE:GROWTH_FACTORS_PRODUCTION
PMID:23010081
Celecoxib (specific COX-2 inhibitor)increases EGF signaling in colon tumor associated fibroblasts, modulating EGFR expression and degradation
and increase colon TAFs proliferation in the presence of EGF.
Also it induces neo-expression and release of Amphiregulin (AREG), a well known EGFR agonist;
EGF signaling induces AREG release.